Muhammed is not the father of any of your men but he is the messenger of Allah and the seal (last) of the prophets {2}, and Allah is the Knower of everything. (R 5)
Refer to Note No.2, Chapter:33 Verse 40 of Explanatory Notes.
Prophethood remained only in the progeny of Ibrahim through his sons Ismael and Ishaq. The last prophets among the descendants of Ishaq were Isa ibni Maryam and Yahya who were not married and were childless. The last prophet among the descendants of Ismael was Muhammed (PBH) whose sons died in childhood. In view of this, prophethood in the progeny of Ibrahim was not carried forward. This proves that Prophet Muhammed (PBH) was the last and the seal of prophethood.